AIIMS NOV 2012 PATHOLOGY

PATHOLOGY

1.  Flow cytometry is  done in:    

a.       Polycythemia

b.      Thrombocytosis

c.       Neutrophilia

d.      Lymphocytosis

Answer: (d) Lymphocytosis

2.  Which of these does not indicate megaloblastic anemia  

a.       Increased reticulocyte count

b.      Raised Bilirubin

c.       Mild splenomegaly

d.      Nucleated RBC

                        Answer:- A. Increased Reticulocyte Count

3.  Myelo-fibrosis leading to a dry tap on bone marrow aspiration is seen with which of the following  condition

a.       Burkitt’s lymphoma

b.      Acute erythroblastic leukemia

c.       Acute megakaryocytic leukemia

d.      Acute undifferentiated leukemia

Answer: (c)   Acute megakaryocytic leukemia.

4.  Receptor on neuronal membrane that induces development of Glioma

a.       CD44

b.      CD133

c.       CD33

d.      CD24

Answer : (b) CD133

5.  CD 95 is a marker of       

a.       Intrinsic pathway of apoptosis

b.      Extrinsic pathway of apoptosis

c.       Necrosis of cell           

d.      Not recalled

Answer. (b) Extrinsic pathway of apoptosis

6.  Marker of myeloid cancers

a.       S100

b.      HMB45

c.       Common leukocyte antigen

d.      Cyto-keratin

Answer. (C) Common leukocyte antigen

7  Adult Patient presents with Generalized lymphadenopathy and blood film shows 70% immature looking lymphocytes

a.       Genotyping/karyotyping

b.      Immunophenotyping

c.       Bone marrow

d.      Peripheral smear study

Answer. B, Immuno-phenotyping

8.  Most common  fixative used in electron microscopy

a.       Glutaraldehyde

b.      Formalin

c.       Picric acid

d.      Absolute Alcohol

Answer. (A) Glutaraldehyde

9.  In a specimen of kidney, fibrinoid necrosis is seen and onion peel appearance is also present. Most probable pathology is

a.       Hyaline degeneration

b.      Hyperplastic arteriosclerosis

c.       Glomerulosclerosis

d.      Fibrillary glomerulonephritis

Answer: B, Hyperplastic arteriosclerosis

10.  Staining done for sebaceous cell carcinoma  ?

a.       Oil Red O

b.      PAS

c.       Methamine silver

d.      Not Recalled

Answer:(a) , Oil Red O

11.  Mutation in CoL4A5 chain the diagnosis

a.       Alports syndrome

b.      Good pasture’s syndrome  

c.       Thin membrane disease

d.      Nodular glomerulosclerosis

Answer: Alport’s syndrome

12.  Person having heterozygous sickle cell trait are protected from infection of

a.       P. falciparum

b.      P. viavax

c.       Pneumococcous

d.      Solmonella

Answer: (a) P. Falciparum

13.  Hyperacute rejection is due to

a.       Preformed antibodies

b.      Cytotoxic T-lymphocyte medicated injury

c.       Circulating macrophage mediated  injury

d.      Endothelitis caused by donor antibodies

Answer: (a) Preformed antibodies

14.  True all except

a.       Omega-3 fatty acid (abundant in fish oil) decrease LDL

b.      Atherosclerosis in less important in age more than 45 years age

c.       Cigarette smoking is independent  risk  factor for M.I

d.      Not recalled

Answer: (b) Atherosclerosis in less important in age more than 45 year’s age